Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2621952..2623540 Replicon chromosome
Accession NZ_LR890564
Organism Klebsiella pneumoniae isolate KSB2_9A-sc-2280332

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW10_RS12790 Protein ID WP_040148030.1
Coordinates 2621952..2623274 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW10_RS12795 Protein ID WP_002904790.1
Coordinates 2623274..2623540 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW10_RS12775 2617008..2619509 + 2502 WP_201506343.1 fimbrial biogenesis outer membrane usher protein -
JMW10_RS12780 2619497..2620501 + 1005 WP_040148029.1 type 1 fimbrial protein -
JMW10_RS12785 2620643..2621935 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW10_RS12790 2621952..2623274 - 1323 WP_040148030.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW10_RS12795 2623274..2623540 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW10_RS12800 2623805..2624131 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMW10_RS12805 2624128..2624628 - 501 WP_040148032.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW10_RS12810 2624606..2625985 - 1380 WP_099745200.1 purine permease -
JMW10_RS12815 2626331..2627485 + 1155 WP_040148035.1 FAD-dependent urate hydroxylase HpxO -
JMW10_RS12820 2627466..2628389 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5366

>T291428 WP_040148030.1 NZ_LR890564:c2623274-2621952 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291428 WP_002904790.1 NZ_LR890564:c2623540-2623274 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References