Detailed information of TA system TA291412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4803982..4805663
• Replicon: chromosome
• Accession: NZ_LR890562
• Organism: Klebsiella pneumoniae isolate INF247-sc-2280148

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: JMW77_RS23575
• Protein ID: WP_201526977.1
• Coordinates: 4803982..4804899 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: JMW77_RS23580
• Protein ID: WP_004177809.1
• Coordinates: 4804905..4805663 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMW77_RS23555	4799288..4800808	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
JMW77_RS23560	4800805..4801803	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMW77_RS23565	4801834..4802775	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMW77_RS23570	4802850..4803857	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
JMW77_RS23575	4803982..4804899	-	918	WP_201526977.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMW77_RS23580	4804905..4805663	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMW77_RS23585	4805749..4806477	-	729	WP_004177810.1	response regulator transcription factor	-
JMW77_RS23590	4806750..4808897	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMW77_RS23595	4808894..4809037	-	144	WP_022631365.1	hypothetical protein	-
JMW77_RS23600	4809475..4810161	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.14 Da
• Isoelectric Point: 5.7845

>T291412 WP_201526977.1 NZ_LR890562:c4804899-4803982 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGKLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT291412 WP_004177809.1 NZ_LR890562:c4805663-4804905 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05