Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2579720..2581308 Replicon chromosome
Accession NZ_LR890562
Organism Klebsiella pneumoniae isolate INF247-sc-2280148

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JMW77_RS12745 Protein ID WP_004213069.1
Coordinates 2579720..2581042 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMW77_RS12750 Protein ID WP_004176198.1
Coordinates 2581042..2581308 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW77_RS12730 2574776..2577277 + 2502 WP_009485242.1 fimbrial biogenesis outer membrane usher protein -
JMW77_RS12735 2577265..2578269 + 1005 WP_048337093.1 type 1 fimbrial protein -
JMW77_RS12740 2578411..2579703 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW77_RS12745 2579720..2581042 - 1323 WP_004213069.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW77_RS12750 2581042..2581308 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW77_RS12755 2581694..2582020 - 327 WP_004215084.1 hydroxyisourate hydrolase -
JMW77_RS12760 2582017..2582517 - 501 WP_004215086.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW77_RS12765 2582495..2583874 - 1380 WP_004215088.1 purine permease -
JMW77_RS12770 2584220..2585374 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW77_RS12775 2585355..2586278 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2381040..2623796 242756


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.5357

>T291407 WP_004213069.1 NZ_LR890562:c2581042-2579720 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291407 WP_004176198.1 NZ_LR890562:c2581308-2581042 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References