Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1758578..1759168 Replicon chromosome
Accession NZ_LR890562
Organism Klebsiella pneumoniae isolate INF247-sc-2280148

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag JMW77_RS08570 Protein ID WP_023341911.1
Coordinates 1758836..1759168 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag JMW77_RS08565 Protein ID WP_000288812.1
Coordinates 1758578..1758835 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW77_RS08540 1755178..1756527 - 1350 WP_077254247.1 DNA (cytosine-5-)-methyltransferase -
JMW77_RS08545 1756535..1756951 - 417 WP_124047552.1 hypothetical protein -
JMW77_RS08550 1757281..1757679 + 399 WP_115657462.1 ash family protein -
JMW77_RS08555 1757579..1758040 + 462 WP_040210976.1 hypothetical protein -
JMW77_RS08560 1758037..1758243 + 207 WP_022615589.1 helix-turn-helix domain-containing protein -
JMW77_RS08565 1758578..1758835 + 258 WP_000288812.1 antitoxin Antitoxin
JMW77_RS08570 1758836..1759168 + 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JMW77_RS08580 1759490..1760926 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
JMW77_RS08590 1761292..1762746 - 1455 WP_004148975.1 AMP nucleosidase -
JMW77_RS08595 1762876..1763121 - 246 WP_048337159.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T291402 WP_023341911.1 NZ_LR890562:1758836-1759168 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT291402 WP_000288812.1 NZ_LR890562:1758578-1758835 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References