Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4647781..4648438 Replicon chromosome
Accession NZ_LR890556
Organism Klebsiella pneumoniae isolate INF302-sc-2280090

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag JMW84_RS22465 Protein ID WP_002916310.1
Coordinates 4648028..4648438 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMW84_RS22460 Protein ID WP_002916312.1
Coordinates 4647781..4648047 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW84_RS22435 4642989..4644422 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
JMW84_RS22440 4644541..4645269 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMW84_RS22445 4645319..4645630 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMW84_RS22450 4645794..4646453 + 660 WP_002916317.1 hemolysin III family protein -
JMW84_RS22455 4646552..4647535 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
JMW84_RS22460 4647781..4648047 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMW84_RS22465 4648028..4648438 + 411 WP_002916310.1 protein YgfX Toxin
JMW84_RS22470 4648445..4648966 - 522 WP_004144730.1 flavodoxin FldB -
JMW84_RS22475 4649067..4649963 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMW84_RS22480 4649986..4650699 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMW84_RS22485 4650705..4652438 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T291397 WP_002916310.1 NZ_LR890556:4648028-4648438 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291397 WP_002916312.1 NZ_LR890556:4647781-4648047 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References