Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4014768..4015387 Replicon chromosome
Accession NZ_LR890547
Organism Klebsiella pneumoniae isolate INF142-sc-2279977

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag JMX11_RS19665 Protein ID WP_002892050.1
Coordinates 4015169..4015387 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag JMX11_RS19660 Protein ID WP_099595242.1
Coordinates 4014768..4015142 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX11_RS19650 4009920..4011113 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMX11_RS19655 4011136..4014282 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
JMX11_RS19660 4014768..4015142 + 375 WP_099595242.1 Hha toxicity modulator TomB Antitoxin
JMX11_RS19665 4015169..4015387 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
JMX11_RS19670 4015546..4016112 + 567 WP_002892030.1 maltose O-acetyltransferase -
JMX11_RS19675 4016084..4016224 - 141 WP_004147370.1 hypothetical protein -
JMX11_RS19680 4016245..4016715 + 471 WP_002892026.1 YlaC family protein -
JMX11_RS19685 4016690..4018141 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
JMX11_RS19690 4018242..4018940 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
JMX11_RS19695 4018937..4019077 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
JMX11_RS19700 4019077..4019340 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T291362 WP_002892050.1 NZ_LR890547:4015169-4015387 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14402.08 Da        Isoelectric Point: 4.8989

>AT291362 WP_099595242.1 NZ_LR890547:4014768-4015142 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFAFNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References