Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2660688..2662276 Replicon chromosome
Accession NZ_LR890547
Organism Klebsiella pneumoniae isolate INF142-sc-2279977

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag JMX11_RS13000 Protein ID WP_004199851.1
Coordinates 2660688..2662010 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMX11_RS13005 Protein ID WP_002904790.1
Coordinates 2662010..2662276 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX11_RS12985 2655753..2658254 + 2502 WP_004199853.1 fimbrial biogenesis outer membrane usher protein -
JMX11_RS12990 2658242..2659246 + 1005 WP_004199852.1 type 1 fimbrial protein -
JMX11_RS12995 2659379..2660671 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX11_RS13000 2660688..2662010 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX11_RS13005 2662010..2662276 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX11_RS13010 2662542..2662868 - 327 WP_002904788.1 hydroxyisourate hydrolase -
JMX11_RS13015 2662865..2663365 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX11_RS13020 2663343..2664722 - 1380 WP_004199850.1 purine permease -
JMX11_RS13025 2665068..2665853 + 786 Protein_2550 FAD-dependent monooxygenase -
JMX11_RS13030 2665921..2667113 + 1193 WP_085955245.1 IS3-like element ISKpn18 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T291361 WP_004199851.1 NZ_LR890547:c2662010-2660688 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291361 WP_002904790.1 NZ_LR890547:c2662276-2662010 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References