Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 18107..18632 Replicon plasmid 4
Accession NZ_LR890545
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name ccdB Uniprot ID A0A9E1GGX2
Locus tag JMX54_RS28260 Protein ID WP_016946795.1
Coordinates 18327..18632 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A9E1GDP8
Locus tag JMX54_RS28255 Protein ID WP_004197642.1
Coordinates 18107..18325 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS28235 13877..14185 + 309 WP_017896554.1 hypothetical protein -
JMX54_RS28240 15410..15901 - 492 WP_032249453.1 hypothetical protein -
JMX54_RS28245 16035..17267 - 1233 WP_032249456.1 hypothetical protein -
JMX54_RS28250 17264..17512 - 249 WP_004200907.1 hypothetical protein -
JMX54_RS28255 18107..18325 + 219 WP_004197642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JMX54_RS28260 18327..18632 + 306 WP_016946795.1 type II toxin-antitoxin system toxin CcdB Toxin
JMX54_RS28265 18790..19473 + 684 WP_023280892.1 hypothetical protein -
JMX54_RS28270 19476..20252 + 777 WP_160458681.1 site-specific integrase -
JMX54_RS28275 20310..20567 - 258 WP_000764642.1 hypothetical protein -
JMX54_RS28280 20696..20800 - 105 WP_032409716.1 hypothetical protein -
JMX54_RS28285 21335..22201 + 867 WP_004118283.1 replication initiation protein -
JMX54_RS28290 22558..22827 - 270 WP_000339857.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(6)-Id / aph(3'')-Ib mrkC / mrkD / mrkF / mrkJ / mrkA / mrkB 1..73736 73736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11548.22 Da        Isoelectric Point: 5.6831

>T291352 WP_016946795.1 NZ_LR890545:18327-18632 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDDSYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8376.34 Da        Isoelectric Point: 4.7405

>AT291352 WP_004197642.1 NZ_LR890545:18107-18325 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References