291351

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 11373..12109 Replicon plasmid 4
Accession NZ_LR890545
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag JMX54_RS28215 Protein ID WP_003026803.1
Coordinates 11373..11855 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMX54_RS28220 Protein ID WP_003026799.1
Coordinates 11843..12109 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS28195 7333..8358 - 1026 WP_001101446.1 IS110 family transposase -
JMX54_RS28200 8526..8723 + 198 Protein_8 IS3 family transposase -
JMX54_RS28205 8951..9655 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
JMX54_RS28210 9815..11161 - 1347 WP_077251107.1 ISNCY family transposase -
JMX54_RS28215 11373..11855 - 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
JMX54_RS28220 11843..12109 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMX54_RS28225 12354..12788 - 435 WP_001567367.1 cell envelope integrity protein TolA -
JMX54_RS28230 12835..13383 - 549 WP_001567366.1 thioredoxin fold domain-containing protein -
JMX54_RS28235 13877..14185 + 309 WP_017896554.1 hypothetical protein -
JMX54_RS28240 15410..15901 - 492 WP_032249453.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aph(6)-Id / aph(3'')-Ib mrkC / mrkD / mrkF / mrkJ / mrkA / mrkB 1..73736 73736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T291351 WP_003026803.1 NZ_LR890545:c11855-11373 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291351 WP_003026799.1 NZ_LR890545:c12109-11843 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References