Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 246967..247489 Replicon plasmid 2
Accession NZ_LR890543
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag JMX54_RS27460 Protein ID WP_004181778.1
Coordinates 246967..247251 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag JMX54_RS27465 Protein ID WP_004181777.1
Coordinates 247241..247489 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS27430 242168..243263 + 1096 Protein_241 conjugal transfer protein TraG N-terminal domain-containing protein -
JMX54_RS27435 243362..244549 - 1188 WP_040209642.1 transposase -
JMX54_RS27440 244585..245013 + 429 WP_077257669.1 IS200/IS605 family transposase -
JMX54_RS27445 245092..245316 + 225 Protein_244 transposase -
JMX54_RS27450 245587..246813 - 1227 WP_040209639.1 transposase -
JMX54_RS27455 246849..246950 + 102 Protein_246 IS200/IS605 family transposase -
JMX54_RS27460 246967..247251 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX54_RS27465 247241..247489 - 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JMX54_RS27470 247780..249579 + 1800 WP_004181776.1 ATP-dependent helicase -
JMX54_RS27475 249913..250899 + 987 WP_025368599.1 hypothetical protein -
JMX54_RS27480 251044..251397 + 354 WP_004181774.1 hypothetical protein -
JMX54_RS27485 251459..252280 + 822 WP_004181772.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..268509 268509


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T291350 WP_004181778.1 NZ_LR890543:c247251-246967 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT291350 WP_004181777.1 NZ_LR890543:c247489-247241 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References