Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 99095..100005 Replicon plasmid 2
Accession NZ_LR890543
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name - Uniprot ID A0A2N4Z2R0
Locus tag JMX54_RS26710 Protein ID WP_004197882.1
Coordinates 99095..99565 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag JMX54_RS26715 Protein ID WP_004181895.1
Coordinates 99562..100005 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS26695 95322..96854 + 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
JMX54_RS26700 96982..98163 + 1182 WP_061891937.1 IS481 family transposase -
JMX54_RS26705 98725..98985 + 261 WP_004026352.1 hypothetical protein -
JMX54_RS26710 99095..99565 - 471 WP_004197882.1 RES family NAD+ phosphorylase Toxin
JMX54_RS26715 99562..100005 - 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
JMX54_RS26720 100106..101377 - 1272 WP_004197886.1 translesion error-prone DNA polymerase V subunit UmuC -
JMX54_RS26725 101377..101799 - 423 WP_004197884.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
JMX54_RS26730 101885..103372 - 1488 WP_201550791.1 group II intron reverse transcriptase/maturase -
JMX54_RS26735 104063..104467 - 405 Protein_102 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..268509 268509


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17633.92 Da        Isoelectric Point: 4.5152

>T291349 WP_004197882.1 NZ_LR890543:c99565-99095 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDFFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT291349 WP_004181895.1 NZ_LR890543:c100005-99562 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4Z2R0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References