291348

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 82523..83049 Replicon plasmid 2
Accession NZ_LR890543
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMX54_RS26615 Protein ID WP_000323025.1
Coordinates 82523..82810 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag JMX54_RS26620 Protein ID WP_004196370.1
Coordinates 82810..83049 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS26585 77566..77799 - 234 WP_004196327.1 hypothetical protein -
JMX54_RS26590 77878..78225 - 348 WP_004196344.1 hypothetical protein -
JMX54_RS26595 78381..79448 - 1068 WP_004181903.1 hypothetical protein -
JMX54_RS26600 80138..80515 + 378 WP_004196351.1 hypothetical protein -
JMX54_RS26605 80713..81687 - 975 WP_004196336.1 hypothetical protein -
JMX54_RS26610 82293..82451 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
JMX54_RS26615 82523..82810 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMX54_RS26620 82810..83049 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMX54_RS26625 83300..83665 + 366 WP_009651956.1 hypothetical protein -
JMX54_RS26630 83709..84446 + 738 WP_008460272.1 HupE/UreJ family protein -
JMX54_RS26635 84460..85149 + 690 WP_004196322.1 hypothetical protein -
JMX54_RS26640 85180..86556 - 1377 WP_004196363.1 chromate efflux transporter -
JMX54_RS26645 86513..87490 - 978 WP_004196334.1 chromate resistance protein -
JMX54_RS26650 87520..87712 + 193 Protein_85 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..268509 268509


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291348 WP_000323025.1 NZ_LR890543:c82810-82523 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT291348 WP_004196370.1 NZ_LR890543:c83049-82810 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References