Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5286314..5286939 | Replicon | chromosome |
Accession | NZ_LR890542 | ||
Organism | Klebsiella pneumoniae isolate INF319-sc-2280116 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | JMX54_RS25860 | Protein ID | WP_002882817.1 |
Coordinates | 5286314..5286697 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | JMX54_RS25865 | Protein ID | WP_004150355.1 |
Coordinates | 5286697..5286939 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMX54_RS25845 | 5283680..5284582 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
JMX54_RS25850 | 5284579..5285214 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
JMX54_RS25855 | 5285211..5286140 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
JMX54_RS25860 | 5286314..5286697 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JMX54_RS25865 | 5286697..5286939 | - | 243 | WP_004150355.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
JMX54_RS25870 | 5287144..5288061 | + | 918 | WP_004181612.1 | alpha/beta hydrolase | - |
JMX54_RS25875 | 5288075..5289016 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
JMX54_RS25880 | 5289061..5289498 | - | 438 | WP_002882809.1 | D-tyrosyl-tRNA(Tyr) deacylase | - |
JMX54_RS25885 | 5289495..5290355 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
JMX54_RS25890 | 5290349..5290948 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T291347 WP_002882817.1 NZ_LR890542:c5286697-5286314 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |