Detailed information of TA system TA291346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4965934..4967615
• Replicon: chromosome
• Accession: NZ_LR890542
• Organism: Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A2L0KL13
• Locus tag: JMX54_RS24375
• Protein ID: WP_019704723.1
• Coordinates: 4965934..4966851 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: JMX54_RS24380
• Protein ID: WP_048986692.1
• Coordinates: 4966857..4967615 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMX54_RS24355	4961240..4962760	+	1521	WP_048986694.1	sugar ABC transporter ATP-binding protein	-
JMX54_RS24360	4962757..4963755	+	999	WP_002885172.1	ribose ABC transporter permease	-
JMX54_RS24365	4963786..4964727	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
JMX54_RS24370	4964802..4965809	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
JMX54_RS24375	4965934..4966851	-	918	WP_019704723.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
JMX54_RS24380	4966857..4967615	-	759	WP_048986692.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
JMX54_RS24385	4967701..4968429	-	729	WP_002885152.1	response regulator transcription factor	-
JMX54_RS24390	4968702..4970849	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
JMX54_RS24395	4971079..4971765	+	687	WP_201550513.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34632.07 Da
• Isoelectric Point: 5.4707

>T291346 WP_019704723.1 NZ_LR890542:c4966851-4965934 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28547.94 Da
• Isoelectric Point: 10.1683

>AT291346 WP_048986692.1 NZ_LR890542:c4967615-4966857 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKQ

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A0A2L0KL13