Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2580386..2581974 Replicon chromosome
Accession NZ_LR890542
Organism Klebsiella pneumoniae isolate INF319-sc-2280116

Toxin (Protein)


Gene name hipA Uniprot ID A0A2X3IYA0
Locus tag JMX54_RS12565 Protein ID WP_032103210.1
Coordinates 2580386..2581708 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JMX54_RS12570 Protein ID WP_004176198.1
Coordinates 2581708..2581974 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX54_RS12550 2575442..2577943 + 2502 WP_048986980.1 fimbrial biogenesis outer membrane usher protein -
JMX54_RS12555 2577931..2578935 + 1005 WP_048986982.1 type 1 fimbrial protein -
JMX54_RS12560 2579077..2580369 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMX54_RS12565 2580386..2581708 - 1323 WP_032103210.1 type II toxin-antitoxin system HipA family toxin Toxin
JMX54_RS12570 2581708..2581974 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMX54_RS12575 2582239..2582565 - 327 WP_048986984.1 hydroxyisourate hydrolase -
JMX54_RS12580 2582562..2583062 - 501 WP_023282573.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMX54_RS12585 2583040..2584419 - 1380 WP_004184021.1 purine permease -
JMX54_RS12590 2584765..2585918 + 1154 Protein_2463 FAD-dependent urate hydroxylase HpxO -
JMX54_RS12595 2585899..2586822 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49097.38 Da        Isoelectric Point: 7.5357

>T291341 WP_032103210.1 NZ_LR890542:c2581708-2580386 [Klebsiella pneumoniae]
MATLTTWMNNVRVGSLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT291341 WP_004176198.1 NZ_LR890542:c2581974-2581708 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X3IYA0

Antitoxin

Source ID Structure

References