291332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 130945..131588 Replicon plasmid 2
Accession NZ_LR890537
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name vagD Uniprot ID C7S9Y5
Locus tag JMX06_RS26170 Protein ID WP_001034046.1
Coordinates 131172..131588 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID V0SR71
Locus tag JMX06_RS26165 Protein ID WP_001261278.1
Coordinates 130945..131175 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS26135 126456..126761 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB -
JMX06_RS26140 126763..126981 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
JMX06_RS26145 127548..128060 + 513 WP_000151784.1 hypothetical protein -
JMX06_RS26150 128094..129227 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
JMX06_RS26155 129394..130167 - 774 WP_000905949.1 hypothetical protein -
JMX06_RS26160 130180..130680 - 501 WP_000528931.1 hypothetical protein -
JMX06_RS26165 130945..131175 + 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
JMX06_RS26170 131172..131588 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX06_RS26175 131633..135427 - 3795 WP_001144732.1 hypothetical protein -
JMX06_RS26180 135808..136038 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JMX06_RS26185 136035..136451 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / mph(A) / sul1 / qacE / aadA2 / dfrA12 / qepA4 / catA1 / tet(B) / sitABCD iucA / iucB / iucC / iucD / iutA 1..158162 158162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14978.31 Da        Isoelectric Point: 6.7113

>T291332 WP_001034046.1 NZ_LR890537:131172-131588 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEAVLKNLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCARLDAILPWDRA
AVDATTEVKVALRLAGTPIGPNDTAIAGHAIATGAILVTNNVREFERVPGLVLEDWAG

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8853.07 Da        Isoelectric Point: 4.6437

>AT291332 WP_001261278.1 NZ_LR890537:130945-131175 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDRIILRPLRPSWSSFLELEKADPGFMTEREDVVCDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9NXF9

Antitoxin

Source ID Structure
AlphaFold DB V0SR71

References