291331

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 126456..126981 Replicon plasmid 2
Accession NZ_LR890537
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name ccdB Uniprot ID V0SSI5
Locus tag JMX06_RS26135 Protein ID WP_001159868.1
Coordinates 126456..126761 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag JMX06_RS26140 Protein ID WP_000813634.1
Coordinates 126763..126981 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS26120 122366..123532 - 1167 WP_000772446.1 plasmid-partitioning protein SopA -
JMX06_RS26125 124120..124875 - 756 WP_024946706.1 replication initiation protein RepE -
JMX06_RS26130 125649..126455 - 807 WP_000016982.1 site-specific integrase -
JMX06_RS26135 126456..126761 - 306 WP_001159868.1 type II toxin-antitoxin system toxin CcdB Toxin
JMX06_RS26140 126763..126981 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
JMX06_RS26145 127548..128060 + 513 WP_000151784.1 hypothetical protein -
JMX06_RS26150 128094..129227 - 1134 WP_001542067.1 DUF3800 domain-containing protein -
JMX06_RS26155 129394..130167 - 774 WP_000905949.1 hypothetical protein -
JMX06_RS26160 130180..130680 - 501 WP_000528931.1 hypothetical protein -
JMX06_RS26165 130945..131175 + 231 WP_001261278.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JMX06_RS26170 131172..131588 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / mph(A) / sul1 / qacE / aadA2 / dfrA12 / qepA4 / catA1 / tet(B) / sitABCD iucA / iucB / iucC / iucD / iutA 1..158162 158162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11706.51 Da        Isoelectric Point: 6.4674

>T291331 WP_001159868.1 NZ_LR890537:c126761-126456 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT291331 WP_000813634.1 NZ_LR890537:c126981-126763 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4VUB
PDB 2VUB
PDB 7EPI
PDB 7EPG
PDB 3VUB
PDB 1X75
PDB 1VUB
PDB 7EPJ
PDB 3HPW
PDB 3G7Z

Antitoxin

Source ID Structure
AlphaFold DB A0A829CQY2

References