Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4589344..4589939 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag JMX06_RS22185 Protein ID WP_000239581.1
Coordinates 4589344..4589694 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag JMX06_RS22190 Protein ID WP_001223213.1
Coordinates 4589688..4589939 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS22165 4584799..4585821 - 1023 WP_001550507.1 ABC transporter permease -
JMX06_RS22170 4585835..4587337 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
JMX06_RS22175 4587469..4588425 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMX06_RS22180 4588735..4589265 + 531 WP_000055075.1 inorganic diphosphatase -
JMX06_RS22185 4589344..4589694 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
JMX06_RS22190 4589688..4589939 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMX06_RS22195 4590151..4590492 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMX06_RS22200 4590495..4594274 - 3780 WP_022646473.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T291322 WP_000239581.1 NZ_LR890536:c4589694-4589344 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT291322 WP_001223213.1 NZ_LR890536:c4589939-4589688 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References