291321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4577807..4578329 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag JMX06_RS22125 Protein ID WP_001105433.1
Coordinates 4577807..4578097 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag JMX06_RS22130 Protein ID WP_000212715.1
Coordinates 4578087..4578329 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS22110 4572975..4574630 + 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -
JMX06_RS22115 4575024..4577162 + 2139 WP_032333766.1 anaerobic ribonucleoside-triphosphate reductase -
JMX06_RS22120 4577342..4577806 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX06_RS22125 4577807..4578097 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX06_RS22130 4578087..4578329 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX06_RS22135 4578521..4578907 - 387 WP_001232246.1 cytochrome b562 -
JMX06_RS22140 4579090..4580442 - 1353 WP_032333765.1 metalloprotease PmbA -
JMX06_RS22145 4580536..4581087 + 552 WP_000166270.1 ribosome-associated protein -
JMX06_RS22150 4581237..4582610 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T291321 WP_001105433.1 NZ_LR890536:c4578097-4577807 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT291321 WP_000212715.1 NZ_LR890536:c4578329-4578087 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References