291320

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4478080..4478900 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name yjhX Uniprot ID A0A0V9MKL8
Locus tag JMX06_RS21615 Protein ID WP_001550554.1
Coordinates 4478080..4478337 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag JMX06_RS21620 Protein ID WP_001519303.1
Coordinates 4478349..4478900 (+) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS21595 4473366..4474472 + 1107 WP_001519308.1 N-acetylneuraminate epimerase -
JMX06_RS21600 4474537..4475517 + 981 WP_001519307.1 transposase -
JMX06_RS21605 4476100..4477341 - 1242 Protein_4234 DNA helicase -
JMX06_RS21610 4477404..4477703 + 300 WP_001519304.1 GNAT family N-acetyltransferase -
JMX06_RS21615 4478080..4478337 + 258 WP_001550554.1 hypothetical protein Toxin
JMX06_RS21620 4478349..4478900 + 552 WP_001519303.1 N-acetyltransferase Antitoxin
JMX06_RS21625 4478952..4479113 + 162 WP_001519302.1 hypothetical protein -
JMX06_RS21630 4479150..4479698 + 549 WP_001519301.1 hypothetical protein -
JMX06_RS21635 4479825..4480085 + 261 WP_000084876.1 hypothetical protein -
JMX06_RS21640 4480123..4480239 + 117 Protein_4241 VOC family protein -
JMX06_RS21645 4480484..4481605 + 1122 WP_000010833.1 M42 family metallopeptidase -
JMX06_RS21650 4481602..4481880 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
JMX06_RS21655 4481892..4483205 + 1314 WP_001519300.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4470564..4479113 8549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9744.33 Da        Isoelectric Point: 11.0090

>T291320 WP_001550554.1 NZ_LR890536:4478080-4478337 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKPVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20463.61 Da        Isoelectric Point: 6.8758

>AT291320 WP_001519303.1 NZ_LR890536:4478349-4478900 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCAQALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V9MKL8

Antitoxin

Source ID Structure

References