Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4420054..4420562 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag JMX06_RS21335 Protein ID WP_001534843.1
Coordinates 4420353..4420562 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A0V9L4L3
Locus tag JMX06_RS21330 Protein ID WP_000063161.1
Coordinates 4420054..4420356 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS21315 4416582..4418732 + 2151 WP_001366791.1 pyruvate/proton symporter BtsT -
JMX06_RS21320 4418850..4419053 + 204 WP_001534846.1 YbdD/YjiX family protein -
JMX06_RS21325 4419064..4420020 + 957 WP_001534845.1 GTPase -
JMX06_RS21330 4420054..4420356 - 303 WP_000063161.1 BrnA antitoxin family protein Antitoxin
JMX06_RS21335 4420353..4420562 - 210 WP_001534843.1 BrnT family toxin Toxin
JMX06_RS21340 4420658..4421824 + 1167 WP_001534841.1 restriction endonuclease -
JMX06_RS21345 4421888..4423507 + 1620 WP_001550561.1 type I restriction-modification system subunit M -
JMX06_RS21350 4423497..4424807 + 1311 WP_001534837.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7952.17 Da        Isoelectric Point: 4.9493

>T291319 WP_001534843.1 NZ_LR890536:c4420562-4420353 [Escherichia coli]
MVDYPKRDAISNINAIIVDTFLYIQLGMATMPMEFEWNANKAKSNRVKHGIRFEDAVLVLDDPQRTEPL

Download         Length: 210 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11600.10 Da        Isoelectric Point: 9.4646

>AT291319 WP_000063161.1 NZ_LR890536:c4420356-4420054 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKVLANKFDEDIDYSDIPSSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9L4L3

References