291314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3386786..3387491 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JMX06_RS16290 Protein ID WP_000539521.1
Coordinates 3386786..3387172 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMX06_RS16295 Protein ID WP_001280945.1
Coordinates 3387162..3387491 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS16270 3382790..3383416 + 627 WP_001295292.1 glutathione S-transferase GstB -
JMX06_RS16275 3383413..3384528 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
JMX06_RS16280 3384639..3385022 - 384 WP_000497137.1 biofilm formation regulator BssR -
JMX06_RS16285 3385235..3386560 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JMX06_RS16290 3386786..3387172 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX06_RS16295 3387162..3387491 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JMX06_RS16300 3387561..3388889 - 1329 WP_022645414.1 GGDEF domain-containing protein -
JMX06_RS16305 3388897..3391245 - 2349 WP_022645413.1 EAL domain-containing protein -
JMX06_RS16310 3391422..3392333 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T291314 WP_000539521.1 NZ_LR890536:3386786-3387172 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT291314 WP_001280945.1 NZ_LR890536:3387162-3387491 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References