Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3096411..3097195 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag JMX06_RS14875 Protein ID WP_000613626.1
Coordinates 3096701..3097195 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0A1AEM7
Locus tag JMX06_RS14870 Protein ID WP_024946541.1
Coordinates 3096411..3096704 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS14860 3091572..3092531 - 960 WP_022645527.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
JMX06_RS14865 3093104..3096277 + 3174 WP_022645526.1 ribonuclease E -
JMX06_RS14870 3096411..3096704 + 294 WP_024946541.1 DUF1778 domain-containing protein Antitoxin
JMX06_RS14875 3096701..3097195 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
JMX06_RS14880 3097290..3098243 - 954 WP_022645524.1 flagellar hook-associated protein FlgL -
JMX06_RS14885 3098255..3099898 - 1644 WP_022645523.1 flagellar hook-associated protein FlgK -
JMX06_RS14890 3099964..3100905 - 942 WP_201525307.1 flagellar assembly peptidoglycan hydrolase FlgJ -
JMX06_RS14895 3100905..3102002 - 1098 WP_022645522.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T291313 WP_000613626.1 NZ_LR890536:3096701-3097195 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11039.60 Da        Isoelectric Point: 10.5423

>AT291313 WP_024946541.1 NZ_LR890536:3096411-3096704 [Escherichia coli]
MAAANNIPARRESLNLRIKPAERDLIDRAAKARGKNRSEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB A0A0A1AEM7

References