Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2693722..2694360 Replicon chromosome
Accession NZ_LR890536
Organism Escherichia coli isolate MSB1_8B-sc-2280300

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag JMX06_RS12895 Protein ID WP_000813794.1
Coordinates 2694184..2694360 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JMX06_RS12890 Protein ID WP_001270286.1
Coordinates 2693722..2694138 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX06_RS12870 2688874..2689815 - 942 WP_022645667.1 ABC transporter permease -
JMX06_RS12875 2689816..2690829 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
JMX06_RS12880 2690847..2691992 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
JMX06_RS12885 2692237..2693643 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
JMX06_RS12890 2693722..2694138 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JMX06_RS12895 2694184..2694360 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JMX06_RS12900 2694582..2694812 + 231 WP_000491567.1 DUF2554 family protein -
JMX06_RS12905 2694904..2696865 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JMX06_RS12910 2696938..2697474 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
JMX06_RS12915 2697527..2698738 + 1212 WP_071788120.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T291312 WP_000813794.1 NZ_LR890536:c2694360-2694184 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT291312 WP_001270286.1 NZ_LR890536:c2694138-2693722 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References