Detailed information of TA system TA029131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazE-Fic/MazF-HTH_24
• Location: 1546683..1547739
• Replicon: chromosome
• Accession: NC_020555
• Organism: Helicobacter cinaedi ATCC BAA-847

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HCBAA847_RS07895
• Protein ID: WP_014667079.1
• Coordinates: 1547428..1547739 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: Fic
• Uniprot ID: I7HDK8
• Locus tag: HCBAA847_RS07890
• Protein ID: WP_015453712.1
• Coordinates: 1546683..1547405 (-)
• Length: 241 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCBAA847_RS07860	1541972..1542232	-	261	WP_014667072.1	hypothetical protein	-
HCBAA847_RS07865	1542216..1542785	-	570	WP_002955279.1	metallophosphoesterase	-
HCBAA847_RS07870	1542816..1543196	-	381	WP_002955280.1	Fic family protein	-
HCBAA847_RS07875	1543202..1543567	-	366	WP_002955281.1	hypothetical protein	-
HCBAA847_RS12170	1543683..1544842	-	1160	Protein_1570	transcriptional regulator	-
HCBAA847_RS07885	1544823..1546667	-	1845	WP_015453711.1	hypothetical protein	-
HCBAA847_RS07890	1546683..1547405	-	723	WP_015453712.1	Fic family protein	Antitoxin
HCBAA847_RS07895	1547428..1547739	-	312	WP_014667079.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HCBAA847_RS07900	1547742..1548002	-	261	WP_002955287.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
HCBAA847_RS07905	1548074..1548778	-	705	WP_015453713.1	hypothetical protein	-
HCBAA847_RS07910	1548723..1549118	-	396	WP_002955289.1	hypothetical protein	-
HCBAA847_RS07915	1549160..1549912	-	753	WP_015453714.1	helicase C-terminal domain-containing protein	-
HCBAA847_RS07920	1550213..1551382	-	1170	WP_002955290.1	hypothetical protein	-
HCBAA847_RS07925	1551414..1551872	-	459	WP_015453715.1	hypothetical protein	-
HCBAA847_RS07930	1552100..1552471	+	372	WP_015453716.1	DUF5131 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1301556..1599967	298411

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Fido domain (74-172)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11979.07 Da
• Isoelectric Point: 8.5080

>T29131 WP_014667079.1 NC_020555:c1547739-1547428 [Helicobacter cinaedi CCUG 18818 = ATCC BAA-847]
MRQFEIFWIDLNLTKGAEISKKRPCVIISPNELNYLQTRLVAPITSKGFDAPFRVNFELEGKKSRILCDQIRCVSIDRFL
NKICDLESNKQEALKNILLEMFA

Nucleotide

• Length: 312 bp

>T29131 NC_020555:c1547739-1547428 [Helicobacter cinaedi CCUG 18818 = ATCC BAA-847]
TTGAGGCAGTTTGAGATTTTTTGGATAGATTTAAATCTTACAAAAGGAGCGGAAATTTCTAAAAAAAGACCTTGTGTGAT
TATCTCACCCAATGAATTAAACTATTTACAAACAAGACTTGTCGCGCCTATTACTTCAAAGGGATTTGATGCTCCTTTTA
GAGTAAATTTTGAATTAGAGGGCAAAAAGTCTAGAATCCTGTGCGACCAAATTCGTTGTGTGAGTATAGATAGATTCTTA
AATAAAATTTGTGATTTAGAATCTAATAAGCAAGAGGCTTTAAAAAATATTCTCCTAGAGATGTTCGCTTAA

Antitoxin

Protein

• Length: 241 a.a.
• Molecular weight: 28218.73 Da
• Isoelectric Point: 8.2379

>AT29131 WP_015453712.1 NC_020555:c1547405-1546683 [Helicobacter cinaedi CCUG 18818 = ATCC BAA-847]
MILDNQEYMLDLCIRMAHHSTAIEGNTLTQDETASIILDNFIPRAIKDREFYEVRNYKYLLPYFIEKLKLNTKIDLELIK
FFHSFIMKDLHEEAGKFKTLENAIIGANFETAKPYLVSSLLKDMCDNLYYKLENSKNDEEKIKAILQSHIHFEKIHPFSD
GNGRIGRLLIAYSCFEHNLTPIVIPKGEKAYYISYLRANKIDDVMIDFIKKIQKEEQQRIEKFKSATLSLKNDLKPKNRK

Nucleotide

• Length: 723 bp

>AT29131 NC_020555:c1547405-1546683 [Helicobacter cinaedi CCUG 18818 = ATCC BAA-847]
ATGATATTGGACAATCAAGAATATATGCTAGATTTGTGTATAAGAATGGCTCATCACAGCACAGCAATAGAAGGTAATAC
GCTTACTCAAGATGAAACAGCCTCTATTATCCTAGATAATTTCATTCCAAGAGCAATAAAAGATAGGGAATTTTATGAAG
TAAGAAATTATAAATACCTCTTGCCTTATTTTATAGAAAAACTTAAATTAAATACAAAGATTGACTTAGAACTTATAAAG
TTTTTTCATTCTTTTATAATGAAAGATTTACACGAAGAAGCTGGGAAATTTAAAACTTTAGAAAATGCGATTATAGGTGC
AAATTTTGAAACAGCTAAACCCTATTTGGTATCCTCATTACTTAAAGATATGTGCGACAACCTATATTATAAATTAGAAA
ACTCTAAAAATGATGAGGAAAAAATTAAGGCAATTTTGCAATCCCATATTCATTTTGAGAAAATTCACCCTTTTAGTGAT
GGTAATGGGAGAATAGGCAGGCTTTTGATAGCCTATTCTTGCTTTGAACATAATTTAACGCCCATTGTTATACCTAAAGG
AGAAAAGGCTTACTATATTTCTTATTTAAGAGCAAACAAAATAGATGATGTGATGATTGATTTTATTAAAAAAATTCAAA
AGGAAGAGCAACAAAGGATAGAGAAATTTAAGTCGGCTACTTTAAGTCTTAAGAATGATTTAAAGCCAAAGAATAGAAAA
TAA

Structures

Antitoxin

• AlphaFold DB: I7HDK8