Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 78943..79465 Replicon plasmid 3
Accession NZ_LR890529
Organism Klebsiella pneumoniae isolate INF361-sc-2280198

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag JMW73_RS26345 Protein ID WP_004187019.1
Coordinates 79181..79465 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag JMW73_RS26340 Protein ID WP_004187025.1
Coordinates 78943..79191 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW73_RS26310 76310..76879 - 570 WP_004152117.1 small heat shock protein sHSP20 -
JMW73_RS26315 76914..77195 - 282 WP_013307885.1 helix-turn-helix domain-containing protein -
JMW73_RS26320 77439..77702 - 264 WP_004118208.1 hypothetical protein -
JMW73_RS26325 77717..77980 + 264 WP_004187027.1 transposase -
JMW73_RS26330 77925..78041 + 117 Protein_76 transposase domain-containing protein -
JMW73_RS26335 78229..78653 + 425 Protein_77 IS1 family transposase -
JMW73_RS26340 78943..79191 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
JMW73_RS26345 79181..79465 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW73_RS26350 79481..80836 - 1356 WP_004187017.1 ISNCY family transposase -
JMW73_RS26355 80918..81217 - 300 Protein_81 conjugal transfer protein TraH -
JMW73_RS26360 81215..81698 - 484 Protein_82 hypothetical protein -
JMW73_RS26365 81715..82239 - 525 Protein_83 hypothetical protein -
JMW73_RS26370 83782..84246 + 465 WP_004187010.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ 1..134665 134665
- flank IS/Tn - - 78423..78689 266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T291300 WP_004187019.1 NZ_LR890529:79181-79465 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT291300 WP_004187025.1 NZ_LR890529:78943-79191 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References