Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 65312..66048 Replicon plasmid 3
Accession NZ_LR890529
Organism Klebsiella pneumoniae isolate INF361-sc-2280198

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag JMW73_RS26255 Protein ID WP_004187044.1
Coordinates 65312..65794 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag JMW73_RS26260 Protein ID WP_003026799.1
Coordinates 65782..66048 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW73_RS26230 61337..62273 - 937 Protein_56 ISNCY family transposase -
JMW73_RS26235 62383..62553 + 171 Protein_57 transposase -
JMW73_RS26240 62551..62658 + 108 Protein_58 IS3 family transposase -
JMW73_RS26245 62891..63595 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
JMW73_RS26250 63755..65101 - 1347 WP_077251107.1 ISNCY family transposase -
JMW73_RS26255 65312..65794 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
JMW73_RS26260 65782..66048 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
JMW73_RS26265 66199..66903 + 705 WP_060579418.1 IS6-like element IS26 family transposase -
JMW73_RS26270 67062..69647 - 2586 WP_004187040.1 EAL domain-containing protein -
JMW73_RS26275 69616..69861 - 246 WP_032238678.1 hypothetical protein -
JMW73_RS26280 69919..70899 - 981 Protein_66 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ 1..134665 134665
- inside IScluster/Tn - - 60174..70899 10725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T291299 WP_004187044.1 NZ_LR890529:c65794-65312 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT291299 WP_003026799.1 NZ_LR890529:c66048-65782 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References