Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4555869..4556385 Replicon chromosome
Accession NZ_LR890527
Organism Klebsiella pneumoniae isolate INF361-sc-2280198

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag JMW73_RS22175 Protein ID WP_009309309.1
Coordinates 4555869..4556153 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag JMW73_RS22180 Protein ID WP_002886901.1
Coordinates 4556143..4556385 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW73_RS22150 4551352..4551660 - 309 WP_016947038.1 PTS sugar transporter subunit IIB -
JMW73_RS22155 4551745..4551918 + 174 WP_002886906.1 hypothetical protein -
JMW73_RS22160 4551921..4552664 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMW73_RS22165 4553021..4555159 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
JMW73_RS22170 4555401..4555865 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMW73_RS22175 4555869..4556153 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMW73_RS22180 4556143..4556385 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMW73_RS22185 4556463..4558373 - 1911 WP_004152270.1 BglG family transcription antiterminator -
JMW73_RS22190 4558396..4559550 - 1155 WP_021313684.1 lactonase family protein -
JMW73_RS22195 4559617..4560357 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T291293 WP_009309309.1 NZ_LR890527:c4556153-4555869 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT291293 WP_002886901.1 NZ_LR890527:c4556385-4556143 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References