Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2592899..2594487 Replicon chromosome
Accession NZ_LR890527
Organism Klebsiella pneumoniae isolate INF361-sc-2280198

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag JMW73_RS12755 Protein ID WP_002904792.1
Coordinates 2592899..2594221 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag JMW73_RS12760 Protein ID WP_002904790.1
Coordinates 2594221..2594487 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW73_RS12740 2587955..2590456 + 2502 WP_004184030.1 fimbrial biogenesis outer membrane usher protein -
JMW73_RS12745 2590444..2591448 + 1005 WP_009308876.1 type 1 fimbrial protein -
JMW73_RS12750 2591590..2592882 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
JMW73_RS12755 2592899..2594221 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
JMW73_RS12760 2594221..2594487 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JMW73_RS12765 2594753..2595079 - 327 WP_201524377.1 hydroxyisourate hydrolase -
JMW73_RS12770 2595076..2595576 - 501 WP_064114890.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
JMW73_RS12775 2595554..2596933 - 1380 WP_104158932.1 purine permease -
JMW73_RS12780 2597279..2598433 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
JMW73_RS12785 2598414..2599337 - 924 WP_104159103.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2398540..2629323 230783


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T291289 WP_002904792.1 NZ_LR890527:c2594221-2592899 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT291289 WP_002904790.1 NZ_LR890527:c2594487-2594221 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References