Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2592899..2594487 | Replicon | chromosome |
Accession | NZ_LR890527 | ||
Organism | Klebsiella pneumoniae isolate INF361-sc-2280198 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | W8UI36 |
Locus tag | JMW73_RS12755 | Protein ID | WP_002904792.1 |
Coordinates | 2592899..2594221 (-) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
Locus tag | JMW73_RS12760 | Protein ID | WP_002904790.1 |
Coordinates | 2594221..2594487 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JMW73_RS12740 | 2587955..2590456 | + | 2502 | WP_004184030.1 | fimbrial biogenesis outer membrane usher protein | - |
JMW73_RS12745 | 2590444..2591448 | + | 1005 | WP_009308876.1 | type 1 fimbrial protein | - |
JMW73_RS12750 | 2591590..2592882 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
JMW73_RS12755 | 2592899..2594221 | - | 1323 | WP_002904792.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
JMW73_RS12760 | 2594221..2594487 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JMW73_RS12765 | 2594753..2595079 | - | 327 | WP_201524377.1 | hydroxyisourate hydrolase | - |
JMW73_RS12770 | 2595076..2595576 | - | 501 | WP_064114890.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
JMW73_RS12775 | 2595554..2596933 | - | 1380 | WP_104158932.1 | purine permease | - |
JMW73_RS12780 | 2597279..2598433 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
JMW73_RS12785 | 2598414..2599337 | - | 924 | WP_104159103.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | mgtC / iroE | 2398540..2629323 | 230783 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.46 Da Isoelectric Point: 7.5357
>T291289 WP_002904792.1 NZ_LR890527:c2594221-2592899 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E1CEC8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GXD8 |