Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1913334..1914970 Replicon chromosome
Accession NC_020547
Organism Acinetobacter baumannii D1279779

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag ABD1_RS09145 Protein ID WP_000737057.1
Coordinates 1913639..1914970 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag ABD1_RS09140 Protein ID WP_001101309.1
Coordinates 1913334..1913642 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABD1_RS09125 1909442..1910896 - 1455 WP_000586249.1 hypothetical protein -
ABD1_RS09130 1910883..1911905 - 1023 WP_000912538.1 MBL fold metallo-hydrolase -
ABD1_RS09135 1912060..1912608 - 549 WP_043961199.1 TetR/AcrR family transcriptional regulator -
ABD1_RS09140 1913334..1913642 - 309 WP_001101309.1 helix-turn-helix domain-containing protein Antitoxin
ABD1_RS09145 1913639..1914970 - 1332 WP_000737057.1 HipA domain-containing protein Toxin
ABD1_RS09150 1915266..1915706 + 441 WP_000193129.1 HD domain-containing protein -
ABD1_RS09155 1915741..1916385 - 645 WP_000817313.1 hypothetical protein -
ABD1_RS09160 1916397..1917368 - 972 WP_086223204.1 5'/3'-nucleotidase SurE -
ABD1_RS09165 1917494..1918657 - 1164 WP_001044484.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51160.29 Da        Isoelectric Point: 4.9820

>T29128 WP_000737057.1 NC_020547:c1914970-1913639 [Acinetobacter baumannii D1279779]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCKLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T29128 NC_020547:c1914970-1913639 [Acinetobacter baumannii D1279779]
ATGAAAAAATTAACGATACAGGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAATATGAATTGGATTATGCCATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACATGAATCGAACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGAATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAATTACTTATTCGTGTTTCACCAGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAAACGTAGCGAGATTGATT
GTGACATTCTGAGAGCCGAATATTATTATTATCAGATACTCAATGAGTTAGGTTTCAACACAATTGAAACAACCCAAATG
AAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTTGAAGTCATTGAAGATC
TATGTAAATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTGTTTGTGAGTGGTTACAACGCGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGGAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GAGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11644.61 Da        Isoelectric Point: 10.1265

>AT29128 WP_001101309.1 NC_020547:c1913642-1913334 [Acinetobacter baumannii D1279779]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPKE

Download         Length: 309 bp

>AT29128 NC_020547:c1913642-1913334 [Acinetobacter baumannii D1279779]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References