Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1714244..1714864 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ISX57_RS25190 Protein ID WP_049120705.1
Coordinates 1714244..1714561 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ISX57_RS25195 Protein ID WP_194131478.1
Coordinates 1714565..1714864 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS25180 1710753..1712186 - 1434 WP_006490987.1 aldehyde dehydrogenase family protein -
ISX57_RS25185 1712215..1713855 - 1641 WP_006490980.1 acetolactate synthase large subunit -
ISX57_RS25190 1714244..1714561 + 318 WP_049120705.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISX57_RS25195 1714565..1714864 + 300 WP_194131478.1 putative addiction module antidote protein Antitoxin
ISX57_RS25200 1714913..1716199 - 1287 WP_194131479.1 DUF445 domain-containing protein -
ISX57_RS25205 1716305..1717525 - 1221 WP_194131480.1 FAD-dependent oxidoreductase -
ISX57_RS25210 1717515..1717841 - 327 WP_006496019.1 non-heme iron oxygenase ferredoxin subunit -
ISX57_RS25215 1717877..1718353 - 477 WP_006490977.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
ISX57_RS25220 1718369..1719640 - 1272 WP_194131481.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11769.46 Da        Isoelectric Point: 8.0598

>T291278 WP_049120705.1 NZ_LR890524:1714244-1714561 [Burkholderia cepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRGTIWVILL
CGGDQSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10630.10 Da        Isoelectric Point: 6.9774

>AT291278 WP_194131478.1 NZ_LR890524:1714565-1714864 [Burkholderia cepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARHAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References