Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1355526..1356172 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name vapC Uniprot ID A0A1V2W4R9
Locus tag ISX57_RS23650 Protein ID WP_062885461.1
Coordinates 1355526..1355933 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag ISX57_RS23655 Protein ID WP_006491146.1
Coordinates 1355930..1356172 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS23630 1351421..1352002 - 582 WP_006486232.1 hypothetical protein -
ISX57_RS23635 1351999..1352727 - 729 WP_194132106.1 chemotaxis protein -
ISX57_RS23640 1352750..1355125 - 2376 WP_006495105.1 MCP four helix bundle domain-containing protein -
ISX57_RS23645 1355183..1355410 + 228 WP_194132066.1 hypothetical protein -
ISX57_RS23650 1355526..1355933 - 408 WP_062885461.1 type II toxin-antitoxin system VapC family toxin Toxin
ISX57_RS23655 1355930..1356172 - 243 WP_006491146.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ISX57_RS23660 1356431..1357114 + 684 WP_194132067.1 phospholipase -
ISX57_RS23665 1357189..1358694 - 1506 WP_006491141.1 amino acid permease -
ISX57_RS23670 1358772..1360178 - 1407 WP_006491136.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14936.05 Da        Isoelectric Point: 6.2179

>T291277 WP_062885461.1 NZ_LR890524:c1355933-1355526 [Burkholderia cepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT291277 WP_006491146.1 NZ_LR890524:c1356172-1355930 [Burkholderia cepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2W4R9

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References