Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 836716..837355 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ISX57_RS21410 Protein ID WP_179148689.1
Coordinates 836939..837355 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A364H554
Locus tag ISX57_RS21405 Protein ID WP_006481537.1
Coordinates 836716..836952 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS21390 832438..833127 - 690 WP_077214643.1 hypothetical protein -
ISX57_RS21395 834309..834986 + 678 WP_077176171.1 hypothetical protein -
ISX57_RS21400 834997..836223 - 1227 WP_034202283.1 acyltransferase -
ISX57_RS21405 836716..836952 + 237 WP_006481537.1 DNA-binding protein Antitoxin
ISX57_RS21410 836939..837355 + 417 WP_179148689.1 type II toxin-antitoxin system VapC family toxin Toxin
ISX57_RS21415 837615..838511 + 897 WP_006481531.1 VOC family protein -
ISX57_RS21420 838521..839414 + 894 WP_048988182.1 CoA transferase subunit A -
ISX57_RS21425 839425..840222 + 798 WP_006481539.1 hypothetical protein -
ISX57_RS21430 840231..841160 + 930 WP_077021150.1 enoyl-CoA hydratase -
ISX57_RS21435 841157..842257 + 1101 WP_034202287.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15401.65 Da        Isoelectric Point: 7.4038

>T291276 WP_179148689.1 NZ_LR890524:836939-837355 [Burkholderia cepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEANASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Download         Length: 417 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8710.78 Da        Isoelectric Point: 5.0916

>AT291276 WP_006481537.1 NZ_LR890524:836716-836952 [Burkholderia cepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H554

References