Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 587837..589629 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag ISX57_RS20320 Protein ID WP_194131907.1
Coordinates 587837..588733 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A364H4C6
Locus tag ISX57_RS20325 Protein ID WP_006496928.1
Coordinates 588772..589629 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS20290 583219..584298 - 1080 WP_194131905.1 porin -
ISX57_RS20295 584743..585060 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
ISX57_RS20300 585062..585373 + 312 WP_006489911.1 hypothetical protein -
ISX57_RS20305 585423..586493 + 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
ISX57_RS20310 586486..587256 + 771 WP_194131906.1 SDR family oxidoreductase -
ISX57_RS20315 587291..587818 + 528 WP_006489904.1 cupin domain-containing protein -
ISX57_RS20320 587837..588733 + 897 WP_194131907.1 alpha/beta fold hydrolase Toxin
ISX57_RS20325 588772..589629 + 858 WP_006496928.1 IclR family transcriptional regulator Antitoxin
ISX57_RS20330 589626..590423 + 798 WP_034202180.1 SDR family oxidoreductase -
ISX57_RS20335 590416..592083 + 1668 WP_006496930.1 thiamine pyrophosphate-binding protein -
ISX57_RS20340 592076..592903 + 828 WP_034202181.1 aspartate dehydrogenase -
ISX57_RS20345 592976..594466 + 1491 WP_006487205.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.74 Da        Isoelectric Point: 7.7327

>T291275 WP_194131907.1 NZ_LR890524:587837-588733 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGSMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31371.86 Da        Isoelectric Point: 6.5061

>AT291275 WP_006496928.1 NZ_LR890524:588772-589629 [Burkholderia cepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H4C6

References