Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 466842..467590 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ISX57_RS19745 Protein ID WP_060210861.1
Coordinates 467078..467590 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ISX57_RS19740 Protein ID WP_060210862.1
Coordinates 466842..467081 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS19715 462088..462342 - 255 WP_194131877.1 D-alanyl-D-alanine dipeptidase -
ISX57_RS19720 462555..462794 - 240 WP_077189301.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ISX57_RS19725 462863..463546 - 684 WP_060210863.1 Fe2+-dependent dioxygenase -
ISX57_RS19730 463543..464298 - 756 WP_006485843.1 sel1 repeat family protein -
ISX57_RS19735 464302..466545 - 2244 WP_058903292.1 TonB-dependent siderophore receptor -
ISX57_RS19740 466842..467081 + 240 WP_060210862.1 Arc family DNA-binding protein Antitoxin
ISX57_RS19745 467078..467590 + 513 WP_060210861.1 type II toxin-antitoxin system VapC family toxin Toxin
ISX57_RS19750 467628..468923 - 1296 WP_006485851.1 aspartate carbamoyltransferase -
ISX57_RS19755 469158..469292 + 135 WP_006485835.1 entericidin A/B family lipoprotein -
ISX57_RS19760 469387..469935 - 549 WP_124632997.1 permease -
ISX57_RS19765 470139..471071 - 933 WP_077189305.1 DMT family transporter -
ISX57_RS19770 471250..472047 - 798 WP_006496182.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18803.81 Da        Isoelectric Point: 11.1413

>T291274 WP_060210861.1 NZ_LR890524:467078-467590 [Burkholderia cepacia]
MIPVDTNVMPEPLRREPNAAVIEWLDAQNVETLYLAAISLAELRFGMAALPEGRRRDWLQQSIGQRVLPLFRGRILPFDD
AASRAYASFCARTRAAGNAIAVTDGYIAATAETNGSIVATRDVAPFQALGLRIIDPWAVRFAIAGSFGVPKCKTRRAWRR
VLNRTIRLVP

Download         Length: 513 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8617.88 Da        Isoelectric Point: 4.6104

>AT291274 WP_060210862.1 NZ_LR890524:466842-467081 [Burkholderia cepacia]
MPVITVRNLPDEVHRALRIRAARHGRSTEAEVRDILEQAVLPGGRLELGTLLAEIGREAGDVDIGVLCDEMPTGPMSFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References