Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 249932..251158 Replicon chromosome
Accession NZ_LR890524
Organism Burkholderia cepacia isolate MINF_4A-sc-2280433

Toxin (Protein)


Gene name vapC Uniprot ID A0A364GRG0
Locus tag ISX57_RS18830 Protein ID WP_006498847.1
Coordinates 249932..250513 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ISX57_RS18835 Protein ID WP_194131839.1
Coordinates 250592..251158 (-) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX57_RS18815 245647..247680 - 2034 WP_112751219.1 MacB family efflux pump subunit -
ISX57_RS18820 247683..248876 - 1194 WP_006483156.1 efflux RND transporter periplasmic adaptor subunit -
ISX57_RS18825 249148..249876 - 729 WP_006483165.1 class I SAM-dependent methyltransferase -
ISX57_RS18830 249932..250513 - 582 WP_006498847.1 HD domain-containing protein Toxin
ISX57_RS18835 250592..251158 - 567 WP_194131839.1 helix-turn-helix domain-containing protein Antitoxin
ISX57_RS18840 251206..251844 - 639 WP_077021267.1 hypothetical protein -
ISX57_RS18845 252184..253587 + 1404 WP_194131840.1 DUF308 domain-containing protein -
ISX57_RS18850 253681..254253 + 573 WP_006498849.1 hypothetical protein -
ISX57_RS18855 254332..254721 - 390 WP_006498850.1 OsmC family protein -
ISX57_RS18860 254952..255683 + 732 WP_006498851.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21312.88 Da        Isoelectric Point: 4.9572

>T291273 WP_006498847.1 NZ_LR890524:c250513-249932 [Burkholderia cepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAARDEIVALWDEYEAATSPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20587.56 Da        Isoelectric Point: 10.7753

>AT291273 WP_194131839.1 NZ_LR890524:c251158-250592 [Burkholderia cepacia]
MTASPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAS
STGRMHLMCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLTDGSAVRLVETLDAH

Download         Length: 567 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A364GRG0

Antitoxin

Source ID Structure

References