Detailed information of TA system TA029127

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1256574..1257253
• Replicon: chromosome
• Accession: NC_020547
• Organism: Acinetobacter baumannii D1279779

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ABD1_RS06030
• Protein ID: WP_000838146.1
• Coordinates: 1256574..1256756 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ABD1_RS06035
• Protein ID: WP_000966688.1
• Coordinates: 1256849..1257253 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABD1_RS05995	1251967..1252185	+	219	WP_001277696.1	hypothetical protein	-
ABD1_RS06000	1252294..1252815	+	522	WP_000749905.1	SH3 domain-containing protein	-
ABD1_RS06005	1252912..1253265	+	354	WP_015451462.1	hypothetical protein	-
ABD1_RS06010	1253265..1254407	+	1143	WP_015451463.1	hypothetical protein	-
ABD1_RS06015	1254503..1255420	+	918	WP_000094263.1	hypothetical protein	-
ABD1_RS06020	1255491..1256000	+	510	WP_031959991.1	hypothetical protein	-
ABD1_RS06030	1256574..1256756	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABD1_RS06035	1256849..1257253	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABD1_RS06040	1257335..1257712	+	378	WP_000720074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1223733..1274383	50650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T29127 WP_000838146.1 NC_020547:1256574-1256756 [Acinetobacter baumannii D1279779]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T29127 NC_020547:1256574-1256756 [Acinetobacter baumannii D1279779]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT29127 WP_000966688.1 NC_020547:1256849-1257253 [Acinetobacter baumannii D1279779]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT29127 NC_020547:1256849-1257253 [Acinetobacter baumannii D1279779]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6