Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4347907..4348717 Replicon chromosome
Accession NZ_LR890515
Organism Klebsiella pneumoniae isolate INF281-sc-2280206

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag JMX78_RS21490 Protein ID WP_004178461.1
Coordinates 4348184..4348717 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag JMX78_RS21485 Protein ID WP_002887278.1
Coordinates 4347907..4348173 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX78_RS21465 4343779..4344123 - 345 WP_064162549.1 cation efflux system protein CusF -
JMX78_RS21470 4344141..4345526 - 1386 WP_064162550.1 efflux transporter outer membrane subunit -
JMX78_RS21475 4345698..4346381 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
JMX78_RS21480 4346371..4347804 + 1434 WP_064162551.1 Cu(+)/Ag(+) sensor histidine kinase -
JMX78_RS21485 4347907..4348173 + 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
JMX78_RS21490 4348184..4348717 + 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
JMX78_RS21495 4348765..4349886 - 1122 WP_004214138.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T291261 WP_004178461.1 NZ_LR890515:4348184-4348717 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT291261 WP_002887278.1 NZ_LR890515:4347907-4348173 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References