Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4215961..4216477 Replicon chromosome
Accession NZ_LR890515
Organism Klebsiella pneumoniae isolate INF281-sc-2280206

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JMX78_RS20920 Protein ID WP_040216106.1
Coordinates 4216193..4216477 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JMX78_RS20915 Protein ID WP_064162488.1
Coordinates 4215961..4216203 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX78_RS20900 4211989..4212729 + 741 WP_002886899.1 KDGP aldolase family protein -
JMX78_RS20905 4212796..4213950 + 1155 WP_064162489.1 lactonase family protein -
JMX78_RS20910 4213973..4215883 + 1911 WP_023325426.1 BglG family transcription antiterminator -
JMX78_RS20915 4215961..4216203 + 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMX78_RS20920 4216193..4216477 + 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JMX78_RS20925 4216481..4216945 - 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
JMX78_RS20930 4217253..4219391 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
JMX78_RS20935 4219748..4220491 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
JMX78_RS20940 4220494..4220667 - 174 WP_032425422.1 hypothetical protein -
JMX78_RS20945 4220752..4221060 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T291260 WP_040216106.1 NZ_LR890515:4216193-4216477 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT291260 WP_064162488.1 NZ_LR890515:4215961-4216203 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References