Detailed information of TA system TA029126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 565588..566077
• Replicon: chromosome
• Accession: NC_020546
• Organism: Bifidobacterium thermophilum RBL67

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: M4RB99
• Locus tag: D805_RS02025
• Protein ID: WP_015449982.1
• Coordinates: 565808..566077 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: M4REW7
• Locus tag: D805_RS02020
• Protein ID: WP_015449981.1
• Coordinates: 565588..565824 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D805_RS02015	564226..565308	+	1083	WP_044282335.1	hypothetical protein	-
D805_RS02020	565588..565824	+	237	WP_015449981.1	ribbon-helix-helix domain-containing protein	Antitoxin
D805_RS02025	565808..566077	+	270	WP_015449982.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D805_RS02030	566345..566986	-	642	WP_081602282.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
D805_RS02035	567004..567908	+	905	Protein_402	A/G-specific adenine glycosylase	-
D805_RS02040	567977..568558	+	582	WP_052307709.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	558375..566944	8569

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10358.21 Da
• Isoelectric Point: 10.4616

>T29126 WP_015449982.1 NC_020546:565808-566077 [Bifidobacterium thermophilum RBL67]
MAWKIEIDKGVQRSMKKLDRHVAKRIIAKLREISQLEDPRSTGKALVGNLAGLWRYRVGDYQIVCDIEDEVLLILVVDVA
HRSKVYKRR

Nucleotide

• Length: 270 bp

>T29126 NC_020546:565808-566077 [Bifidobacterium thermophilum RBL67]
TTGGCTTGGAAGATTGAAATCGATAAGGGCGTCCAGCGTTCGATGAAGAAACTGGATCGCCATGTCGCCAAGAGAATCAT
CGCAAAACTTAGGGAAATTTCACAGTTGGAAGATCCAAGAAGCACTGGCAAAGCTCTTGTCGGTAATCTGGCAGGGCTGT
GGCGTTACCGTGTTGGGGACTATCAGATCGTGTGCGATATAGAAGATGAGGTTCTACTGATTCTTGTGGTTGATGTCGCG
CACAGGAGCAAGGTGTACAAGCGCCGTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8876.10 Da
• Isoelectric Point: 4.2821

>AT29126 WP_015449981.1 NC_020546:565588-565824 [Bifidobacterium thermophilum RBL67]
MATATAALRMPVELAARYDRLAKATGRTKTFYMNEALTESIDRLEYEYGIMKKVEDWRAGILETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT29126 NC_020546:565588-565824 [Bifidobacterium thermophilum RBL67]
ATGGCCACGGCTACTGCAGCATTGAGGATGCCTGTCGAATTGGCGGCTCGTTACGATCGTTTGGCGAAAGCAACTGGCCG
TACGAAGACGTTTTATATGAACGAAGCCCTTACCGAGTCAATCGATAGGCTTGAGTATGAATACGGCATTATGAAAAAGG
TTGAGGATTGGCGTGCCGGCATACTCGAGACTGTGACGCTCGACGAGCTGGAGGAAAGCCTTGGCTTGGAAGATTGA

Structures

Toxin

• AlphaFold DB: M4RB99

Antitoxin

• AlphaFold DB: M4REW7