Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3701100..3701725 Replicon chromosome
Accession NZ_LR890515
Organism Klebsiella pneumoniae isolate INF281-sc-2280206

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMX78_RS18410 Protein ID WP_002882817.1
Coordinates 3701342..3701725 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX78_RS18405 Protein ID WP_004150355.1
Coordinates 3701100..3701342 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX78_RS18380 3697091..3697690 + 600 WP_004151865.1 glucose-1-phosphatase -
JMX78_RS18385 3697684..3698544 + 861 WP_004146232.1 virulence factor BrkB family protein -
JMX78_RS18390 3698541..3698978 + 438 WP_064162494.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX78_RS18395 3699023..3699964 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX78_RS18400 3699978..3700895 - 918 WP_004181612.1 alpha/beta hydrolase -
JMX78_RS18405 3701100..3701342 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX78_RS18410 3701342..3701725 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX78_RS18415 3701899..3702828 - 930 WP_064162495.1 formate dehydrogenase accessory protein FdhE -
JMX78_RS18420 3702825..3703460 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX78_RS18425 3703457..3704359 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T291259 WP_002882817.1 NZ_LR890515:3701342-3701725 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291259 WP_004150355.1 NZ_LR890515:3701100-3701342 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References