Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2800020..2800677 Replicon chromosome
Accession NZ_LR890515
Organism Klebsiella pneumoniae isolate INF281-sc-2280206

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag JMX78_RS13915 Protein ID WP_040245400.1
Coordinates 2800020..2800430 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag JMX78_RS13920 Protein ID WP_002916312.1
Coordinates 2800411..2800677 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX78_RS13895 2796020..2797753 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
JMX78_RS13900 2797759..2798472 - 714 WP_048290928.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
JMX78_RS13905 2798495..2799391 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
JMX78_RS13910 2799492..2800013 + 522 WP_002916308.1 flavodoxin FldB -
JMX78_RS13915 2800020..2800430 - 411 WP_040245400.1 protein YgfX Toxin
JMX78_RS13920 2800411..2800677 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
JMX78_RS13925 2800923..2801906 + 984 WP_032430613.1 tRNA-modifying protein YgfZ -
JMX78_RS13930 2802057..2802716 - 660 WP_048334397.1 hemolysin III family protein -
JMX78_RS13935 2802880..2803191 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
JMX78_RS13940 2803241..2803969 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
JMX78_RS13945 2804088..2805521 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T291257 WP_040245400.1 NZ_LR890515:c2800430-2800020 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT291257 WP_002916312.1 NZ_LR890515:c2800677-2800411 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References