Detailed information of TA system TA029125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-Axe/YoeB-RelB
• Location: 105394..105918
• Replicon: chromosome
• Accession: NC_020546
• Organism: Bifidobacterium thermophilum RBL67

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: M4RDV8
• Locus tag: D805_RS00390
• Protein ID: WP_015449616.1
• Coordinates: 105394..105654 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: M4RA88
• Locus tag: D805_RS00395
• Protein ID: WP_015449617.1
• Coordinates: 105658..105918 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D805_RS00370	100741..101715	+	975	WP_015449610.1	zinc metalloprotease HtpX	-
D805_RS00375	101965..102810	+	846	WP_015449612.1	phosphatase PAP2 family protein	-
D805_RS00380	102922..103332	+	411	WP_015449613.1	peptide deformylase	-
D805_RS00385	103724..104905	-	1182	WP_015449614.1	aromatic amino acid DMT transporter YddG	-
D805_RS09450	105179..105337	-	159	WP_015449615.1	hypothetical protein	-
D805_RS00390	105394..105654	-	261	WP_015449616.1	Txe/YoeB family addiction module toxin	Toxin
D805_RS00395	105658..105918	-	261	WP_015449617.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D805_RS00405	106371..106538	-	168	WP_026650596.1	50S ribosomal protein L32	-
D805_RS00410	106538..106660	-	123	WP_015449619.1	type B 50S ribosomal protein L36	-
D805_RS00415	106657..107031	-	375	WP_015449620.1	type B 50S ribosomal protein L31	-
D805_RS00420	107130..107435	-	306	WP_015449621.1	30S ribosomal protein S14	-
D805_RS00425	107437..107604	-	168	WP_015449622.1	50S ribosomal protein L33	-
D805_RS00430	107691..107930	-	240	WP_026650597.1	50S ribosomal protein L28	-
D805_RS00435	107990..108853	+	864	WP_015449624.1	hypothetical protein	-
D805_RS00440	109289..110062	-	774	WP_015449625.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10213.57 Da
• Isoelectric Point: 7.9936

>T29125 WP_015449616.1 NC_020546:c105654-105394 [Bifidobacterium thermophilum RBL67]
MLRWTDDAWEDYLYWQSPDKRTLKRINALIRDAQRSPFEGIGKPEPLKWDFQGAWSRRIDSANRLIYMVADGDLCILSAR
DHYPGR

Nucleotide

• Length: 261 bp

>T29125 NC_020546:c105654-105394 [Bifidobacterium thermophilum RBL67]
ATGCTCCGTTGGACGGATGACGCCTGGGAAGATTACCTGTATTGGCAGTCCCCAGACAAGCGCACGCTGAAACGAATCAA
CGCCCTCATCCGGGACGCGCAACGCTCGCCGTTCGAGGGCATTGGCAAGCCGGAGCCGCTGAAATGGGACTTCCAGGGCG
CTTGGAGCAGACGTATCGATTCAGCGAATCGACTGATTTATATGGTCGCGGACGGCGACCTGTGCATCCTGTCCGCGCGA
GACCACTACCCGGGACGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 5.6765

>AT29125 WP_015449617.1 NC_020546:c105918-105658 [Bifidobacterium thermophilum RBL67]
MVTAVAYTNFRKDLKSYMRRVNDDADMLLVTNKDEHDNVVVMSASDYDSLMETLRVYQNQYLRNKVQRGMEQIREGAATQ
HDITKD

Nucleotide

• Length: 261 bp

>AT29125 NC_020546:c105918-105658 [Bifidobacterium thermophilum RBL67]
ATGGTCACCGCAGTCGCCTACACGAACTTCCGCAAAGATCTGAAATCCTACATGCGCCGGGTCAACGATGACGCGGATAT
GCTGCTTGTGACGAACAAGGATGAACATGACAACGTCGTCGTCATGAGCGCTTCCGATTACGATTCCCTCATGGAAACGC
TCCGGGTGTACCAGAATCAGTATCTGCGCAACAAAGTTCAACGCGGCATGGAGCAGATTCGCGAAGGGGCAGCCACCCAG
CACGACATCACCAAGGATTGA

Structures

Toxin

• AlphaFold DB: M4RDV8

Antitoxin

• AlphaFold DB: M4RA88