Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 37062..37687 Replicon plasmid 2
Accession NZ_LR890509
Organism Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JMW57_RS23115 Protein ID WP_000911317.1
Coordinates 37289..37687 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID L4J1D2
Locus tag JMW57_RS23110 Protein ID WP_000450532.1
Coordinates 37062..37289 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW57_RS23110 37062..37289 + 228 WP_000450532.1 toxin-antitoxin system antitoxin VapB Antitoxin
JMW57_RS23115 37289..37687 + 399 WP_000911317.1 tRNA(fMet)-specific endonuclease VapC Toxin
JMW57_RS23120 37696..39885 - 2190 WP_201524628.1 type IV conjugative transfer system coupling protein TraD -
JMW57_RS23125 40137..40868 - 732 WP_123032535.1 complement resistance protein TraT -
JMW57_RS23130 40900..41397 - 498 WP_097731810.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..91228 91228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14857.14 Da        Isoelectric Point: 8.5264

>T291242 WP_000911317.1 NZ_LR890509:37289-37687 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8512.55 Da        Isoelectric Point: 4.5358

>AT291242 WP_000450532.1 NZ_LR890509:37062-37289 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGNSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHF5

References