Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 2673062..2674050 Replicon chromosome
Accession NZ_LR890508
Organism Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)


Gene name panT Uniprot ID A0A067H892
Locus tag JMW57_RS13025 Protein ID WP_000133216.1
Coordinates 2673062..2673481 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A0J5Z6D5
Locus tag JMW57_RS13030 Protein ID WP_000458584.1
Coordinates 2673478..2674050 (-) Length 191 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW57_RS12980 2668138..2668962 + 825 WP_201524471.1 DUF2303 family protein -
JMW57_RS12985 2669091..2669627 + 537 WP_000008174.1 5'-deoxynucleotidase -
JMW57_RS12990 2669618..2670496 + 879 WP_201524472.1 phosphoadenosine phosphosulfate reductase family protein -
JMW57_RS12995 2670493..2671149 + 657 WP_053884860.1 ead/Ea22-like family protein -
JMW57_RS13000 2671151..2671342 + 192 WP_001014294.1 hypothetical protein -
JMW57_RS13005 2671345..2671911 + 567 WP_201524473.1 DUF551 domain-containing protein -
JMW57_RS13010 2671911..2672483 + 573 WP_001061338.1 3'-5' exoribonuclease -
JMW57_RS13015 2672520..2672801 + 282 WP_001093919.1 pyocin activator PrtN family protein -
JMW57_RS13020 2672849..2673022 - 174 WP_000390073.1 hypothetical protein -
JMW57_RS13025 2673062..2673481 - 420 WP_000133216.1 hypothetical protein Toxin
JMW57_RS13030 2673478..2674050 - 573 WP_000458584.1 SocA family protein Antitoxin
JMW57_RS13035 2674286..2674408 - 123 WP_001300034.1 hypothetical protein -
JMW57_RS13040 2674771..2675756 - 986 Protein_2553 DUF2713 domain-containing protein -
JMW57_RS13045 2676074..2676589 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
JMW57_RS13050 2676631..2676840 - 210 WP_001030593.1 CsbD family protein -
JMW57_RS13055 2676956..2678281 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
JMW57_RS13060 2678354..2678962 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2657395..2678962 21567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-137)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15806.90 Da        Isoelectric Point: 5.8917

>T291232 WP_000133216.1 NZ_LR890508:c2673481-2673062 [Escherichia coli]
MTDYQPYRKGTVLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAI
IWRVDNMVRKQRSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 420 bp

Antitoxin


Download         Length: 191 a.a.        Molecular weight: 21973.21 Da        Isoelectric Point: 6.0283

>AT291232 WP_000458584.1 NZ_LR890508:c2674050-2673478 [Escherichia coli]
MFCEEKVAQMAAYLLLKRGGRMAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYN
LIETNGHNVSLRSDPREMDADEVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLI
SEGKSEDEANRIIGKMEESQKLKEFSLQLS

Download         Length: 573 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A067H892

Antitoxin

Source ID Structure
AlphaFold DB A0A0J5Z6D5

References