Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2468615..2469210 Replicon chromosome
Accession NZ_LR890508
Organism Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag JMW57_RS12005 Protein ID WP_000239577.1
Coordinates 2468615..2468965 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag JMW57_RS12010 Protein ID WP_001223210.1
Coordinates 2468959..2469210 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW57_RS11985 2464061..2465083 - 1023 WP_001313531.1 ABC transporter permease -
JMW57_RS11990 2465097..2466599 - 1503 WP_201524468.1 sugar ABC transporter ATP-binding protein -
JMW57_RS11995 2466739..2467695 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
JMW57_RS12000 2468005..2468535 + 531 WP_000055075.1 inorganic diphosphatase -
JMW57_RS12005 2468615..2468965 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
JMW57_RS12010 2468959..2469210 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
JMW57_RS12015 2469422..2469763 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
JMW57_RS12020 2469766..2473545 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T291230 WP_000239577.1 NZ_LR890508:c2468965-2468615 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT291230 WP_001223210.1 NZ_LR890508:c2469210-2468959 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure

References