Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 594952..595478 Replicon chromosome
Accession NZ_LR890508
Organism Escherichia coli isolate MSB1_9I-sc-2280417

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag JMW57_RS02965 Protein ID WP_000323025.1
Coordinates 595191..595478 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag JMW57_RS02960 Protein ID WP_000534858.1
Coordinates 594952..595191 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMW57_RS02925 591930..592121 - 192 WP_001083297.1 lysis protein YdfD -
JMW57_RS02930 592118..592306 - 189 WP_000854559.1 cell division inhibition protein DicB -
JMW57_RS02935 592411..592632 + 222 WP_024172460.1 hypothetical protein -
JMW57_RS02940 592613..593578 + 966 WP_000054512.1 hypothetical protein -
JMW57_RS02945 593619..593807 + 189 Protein_577 DUF977 family protein -
JMW57_RS02950 594087..594419 - 333 WP_001301033.1 protein FlxA -
JMW57_RS02955 594622..594927 - 306 WP_001326990.1 hypothetical protein -
JMW57_RS02960 594952..595191 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
JMW57_RS02965 595191..595478 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JMW57_RS02970 595550..595705 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
JMW57_RS02975 595889..596287 + 399 Protein_583 antitermination protein -
JMW57_RS02980 596565..596654 - 90 WP_120795389.1 hypothetical protein -
JMW57_RS02985 596709..596921 - 213 WP_000087756.1 cold shock-like protein CspF -
JMW57_RS02990 597222..597437 + 216 WP_000066484.1 cold shock-like protein CspB -
JMW57_RS02995 598191..598406 + 216 WP_000839590.1 phage lysis protein EssD -
JMW57_RS03000 598411..598722 + 312 WP_000189916.1 YdfR family protein -
JMW57_RS03005 598719..599252 + 534 WP_001556614.1 lysozyme -
JMW57_RS03010 599249..599746 + 498 WP_001071769.1 DUF2514 domain-containing protein -
JMW57_RS03015 600109..600321 + 213 WP_000066495.1 cold shock protein CspI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 587727..609599 21872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T291224 WP_000323025.1 NZ_LR890508:595191-595478 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT291224 WP_000534858.1 NZ_LR890508:594952-595191 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References