Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 258871..259483 Replicon chromosome
Accession NC_020540
Organism Streptococcus pyogenes M1 476

Toxin (Protein)


Gene name parE Uniprot ID J7M9F1
Locus tag M1GAS476_RS01365 Protein ID WP_010922665.1
Coordinates 258871..259206 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag M1GAS476_RS01370 Protein ID WP_002988079.1
Coordinates 259196..259483 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1GAS476_RS01330 254249..254767 + 519 WP_002982682.1 NYN domain-containing protein -
M1GAS476_RS01335 254864..255724 + 861 WP_002982687.1 DegV family protein -
M1GAS476_RS01340 255860..256366 + 507 WP_002988070.1 hypothetical protein -
M1GAS476_RS01345 256363..256569 + 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
M1GAS476_RS01350 256787..257233 + 447 WP_002982710.1 50S ribosomal protein L13 -
M1GAS476_RS01355 257254..257646 + 393 WP_002982716.1 30S ribosomal protein S9 -
M1GAS476_RS09900 257766..258203 - 438 WP_076639988.1 site-specific integrase -
M1GAS476_RS09905 258249..258719 - 471 Protein_231 integrase -
M1GAS476_RS01365 258871..259206 - 336 WP_010922665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1GAS476_RS01370 259196..259483 - 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
M1GAS476_RS01375 260144..260917 - 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
M1GAS476_RS01380 261364..261792 + 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
M1GAS476_RS01385 261827..262342 + 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
M1GAS476_RS01390 262390..263319 + 930 WP_010922663.1 tagatose-6-phosphate kinase -
M1GAS476_RS01395 263323..264306 + 984 WP_002982755.1 tagatose-bisphosphate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13185.99 Da        Isoelectric Point: 5.2144

>T29121 WP_010922665.1 NC_020540:c259206-258871 [Streptococcus pyogenes M1 476]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRIVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T29121 NC_020540:c259206-258871 [Streptococcus pyogenes M1 476]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT29121 WP_002988079.1 NC_020540:c259483-259196 [Streptococcus pyogenes M1 476]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT29121 NC_020540:c259483-259196 [Streptococcus pyogenes M1 476]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J7M9F1

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References