Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3701091..3701716 Replicon chromosome
Accession NZ_LR890500
Organism Klebsiella pneumoniae isolate KSB1_5H-sc-2280283

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag JMX76_RS18410 Protein ID WP_002882817.1
Coordinates 3701333..3701716 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag JMX76_RS18405 Protein ID WP_004150355.1
Coordinates 3701091..3701333 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMX76_RS18380 3697082..3697681 + 600 WP_004151865.1 glucose-1-phosphatase -
JMX76_RS18385 3697675..3698535 + 861 WP_004146232.1 virulence factor BrkB family protein -
JMX76_RS18390 3698532..3698969 + 438 WP_064162494.1 D-tyrosyl-tRNA(Tyr) deacylase -
JMX76_RS18395 3699014..3699955 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
JMX76_RS18400 3699969..3700886 - 918 WP_004181612.1 alpha/beta hydrolase -
JMX76_RS18405 3701091..3701333 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
JMX76_RS18410 3701333..3701716 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
JMX76_RS18415 3701890..3702819 - 930 WP_064162495.1 formate dehydrogenase accessory protein FdhE -
JMX76_RS18420 3702816..3703451 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
JMX76_RS18425 3703448..3704350 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T291206 WP_002882817.1 NZ_LR890500:3701333-3701716 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT291206 WP_004150355.1 NZ_LR890500:3701091-3701333 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References