Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4835654..4837335 Replicon chromosome
Accession NZ_LR890493
Organism Klebsiella pneumoniae isolate INF018-sc-2279888

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag JMV82_RS23440 Protein ID WP_023328808.1
Coordinates 4835654..4836571 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag JMV82_RS23445 Protein ID WP_004177809.1
Coordinates 4836577..4837335 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMV82_RS23420 4831035..4832555 + 1521 WP_040147141.1 sugar ABC transporter ATP-binding protein -
JMV82_RS23425 4832552..4833550 + 999 WP_031592479.1 ribose ABC transporter permease -
JMV82_RS23430 4833581..4834522 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
JMV82_RS23435 4834597..4835529 + 933 WP_040147145.1 carbohydrate kinase family protein -
JMV82_RS23440 4835654..4836571 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JMV82_RS23445 4836577..4837335 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JMV82_RS23450 4837421..4838149 - 729 WP_002885152.1 response regulator transcription factor -
JMV82_RS23455 4838422..4840569 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
JMV82_RS23460 4840799..4841485 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T291197 WP_023328808.1 NZ_LR890493:c4836571-4835654 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT291197 WP_004177809.1 NZ_LR890493:c4837335-4836577 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References